![]() ![]() ![]() The PCM content was fixed at 30% w/w in all six compositions. For example, P10UC means that PVP was 10% w/w in the primary powder and only uncoated lactose powder was used. In this work, the six compositions followed the coding rule indicated by PVP percentage and uncoated or coated, namely, P10UC, P10C, P15UC, P15C, P20UC and P20C. Three compositions contained uncoated lactose powder, and the remaining three compositions had the coated lactose powder in addition to the uncoated powder. Six compositions of primary powder were studied ( Table 1). ( European Pharmacopoeia), HPLC ( High-Performance Liquid Chromatography), PCM ( Paracetamol), PVP ( Polyvinylpyrrolidone), SEM ( Scanning Electron Microscope), XRPD ( X-ray Powder Diffraction) KeywordsĪbbreviations: 3D ( Three-dimensional), ACN ( Acetonitrile), API ( Active Pharmaceutical Ingredient), BJ ( Binder Jetting), Ph. ![]() In conclusion, thin layer coating is an effective way to pre-process primary powder particles for BJ 3D printing of oral solid products. Especially for the composition with a relatively small amount of binder (i.e., 10% and 15% w/w PVP in the primary powder), the use of coated particles significantly improved the resistance to crushing and decreased the disintegration time of printed products. The presence of coated lactose in the primary powder increased the interparticulate interactions in the BJ 3D printed products. The primary powder compositions were prepared with or without the coated lactose powder, and they were subsequently 3D BJ printed into oral solid products with paracetamol as a model active drug substance. The investigated compositions of the primary powder contained PVP at three levels, namely, 10 %, 15% and 20% (w/w). With this strategy, the matrix particles (lactose monohydrate) of the primary powder for BJ 3D printing were coated with the binder (polyvinylpyrrolidone, PVP). In this study, a strategy based on pre-processing with a thin layer coating was explored. However, one of the existing challenges related to pharmaceutical applications of BJ is the relatively high amount of binder needed in the primary powder to ensure the sufficient mechanical strength of printed products. Binder jetting (BJ) 3D printing is especially suitable for the fabrication of an orodispersible solid dosage form, as it is an efficient way to avoid the use of mechanical forces typical for compaction-based processes. ![]()
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